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What we do

High-resolution, wide-field camera with outstanding resolution

The Profundus system

Our system is based on advanced adaptive optics (AO), originating from the astronomical community where it is used in ground-based telescopes to correct for atmospheric distortions, and optimized for retinal diagnostics. Compared with other systems on the market, the Profundus camera is being developed to combine several important features and benefits:
  • A stand-alone camera with a small footprint for research and clinical use
  • Less chair time – efficient both for patients and operators
  • Easy to use – requiring a minimum of training
  • Software modules as add-ons providing the possibility to grow with the system
  • Efficient workflow support
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High-resolution, wide-field camera with outstanding resolution

The resolution of the Profundus camera is approximately 2-3 µm, an improvement of up to 10 times compared to traditional fundus cameras that usually provide a resolution of 15-20 µm. Our wide-field feature yields a 7 degree corrected field of view for a single image, up to 8x larger field of view compared to devices based on single-conjugate adaptive optics that only use one corrective element. As a result of combining five images, the corrected field of view increases to 13-14 degrees.

Jörgen Thaung, Per Knutsson, Zoran Popovic, and Mette Owner-Petersen, ”Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging,” Opt. Express 17(6), 4454-4467 (2009).

Zoran Popovic, Per Knutsson, Jörgen Thaung, Mette Owner-Petersen, Johan Sjöstrand, ”Noninvasive imaging of human foveal capillary network using dual-conjugate adaptive optics.” Invest. Ophthalmol. Vis. Sci., 52(5):2649-2655 (2011).

Seeing the invisible – The secrets are in the details

”The PROFUNDUS adaptive optics camera will open the door to potent in vivo diagnostic and prognostic studies of retinal diseases at ultrastructural level. It will open the window to the retina as part of the brain, as well as build wonderful collaborations internationally.”

– Prof. Dr. Goran Petrovski, Senior Consultant and Head of the Center for Eye Research and Innovative Diagnostics, Oslo University Hospital and University of Oslo, Norway

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”Profundus has a unique method for being able to look at the cellular level in the retina, which should be able to generate significant benefits in research and also clinically for large patient groups.”

– Anders Kvanta, Professor of Ophthalmology, Karolinska Institutet, Stockholm, Sweden

Imagery below illustrates the difference between a traditional fundus camera and the Profundus camera when it comes to showing structures of the central part of the retina; capillaries, nerve fibre layer and single cells.

Central region of traditional fundus camera image

Profundus image – capillary level

Profundus image – cellular level

Finding early signs of change – Diabetes

“Adaptive Optics aided cellular imaging gives you a jeweller’s hammer. You are able to make very fine observation of the retinal changes and polish off what we learned with other imaging modalities.”

Adam Dubis, Associate Professor, Deputy Director of Research and Programme Lead for MSc Digital Health and Entrepreneurship at UCL’s Global Business School for Health

One of the major benefits with the Profundus camera is the high resolution, as a result of this it is expected to be able to detect early signs of different diseases, as can be seen when comparing retinal images from a diabetic subject.

Traditional fundus camera zoom: anomalies are hard to identify.

Profundus system shows micoraneurysms making early intervention possible.